抑制PI3K/AKT信号通路对鹿茸干细胞的影响

doi:10.11843/j.issn.0366-6964.2017.11.021

Abstract

Abstract:

Understanding the role of the PI3K/AKT pathway in regulating basic parameters of antler stem cells, include antlerogenic periosteum (AP) cells and pedicle periosteum (PP) cells, and provide valuable insights into the mechanisms underlying mammalian organ generation and regeneration. In the present study, we investigated the effects of the PI3K/AKT pathway on antler stem cell proliferation, adhesion, cell cycle, cytoskeleton and angiogenesis. Our results showed that:1) PI3K/AKT pathway had a greater influence on proliferation of the AP cells and played a more important role in maintaining the normal cell cytoskeleton than those of the PP cells; 2) conditioned medium of the APCs stimulated tube formation,whereas the PPCs did not significantly do so. Our results suggest that PI3K/AKT pathway may play more important role in antler generation than regeneration.

CLC Number:

S825

LIU Zhen, SUN Hong-mei, LI Chun-yi. Differential Effects of Inhibition of the PI3K/AKT Pathway on Antler Stem Cells' Parameters[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2017, 48(11): 2189-2197.

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Differential Effects of Inhibition of the PI3K/AKT Pathway on Antler Stem Cells' Parameters

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